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P164 IDS

SALSA MLPA Probemix P164 IDS detects copy number variations in the IDS gene.

Specifications

Contents: 24 MLPA probes, including 11 probes for IDS.

Tissue: human genomic DNA.

Application: research on Hunter syndrome.

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

General information

The SALSA MLPA Probemix P164 IDS is a research use only (RUO) assay for the detection of deletions or duplications in the IDS gene, which is associated with Hunter syndrome.

Defects in the Iduronate 2-sulfatase (IDS) gene on chromosome X are the cause of mucopolysaccharidosis type II (MPS II) or Hunter syndrome. Partial deletions or complete IDS gene deletions are estimated to be the cause of disease in 20% of all cases. Patients with full deletions or gross rearrangements of the IDS gene have in general a severe clinical presentation. However, most individuals with Hunter syndrome have point mutations in the IDS gene, none of which will be detected by the MLPA technique.

A pseudogene of IDS gene (IDSP1) is located at short distance of the real gene. A recombination event between the IDS gene and the IDSP1 pseudogene is the cause of disease in an estimated 13% of the Hunter syndrome patients. In most patients this recombination results in an inversion. It is probably not possible to detect most inversions with this MLPA assay. In view of the close distance and high similarity between the IDS and IDSP1 genes, gene conversion might occur and great care should be taken with interpretation of results obtained with this P164-B3 probemix.

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK1274/.

Regulatory status

SALSA MLPA Probemix P164 IDS is for research use only (RUO) in all territories.

Product documentation

Version B3

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P164-025R
SALSA MLPA Probemix P164 IDS – 25 rxn
MLPA
€ 286.00
P164-050R
SALSA MLPA Probemix P164 IDS – 50 rxn
MLPA
€ 560.00
P164-100R
SALSA MLPA Probemix P164 IDS – 100 rxn
MLPA
€ 1096.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 348.00
EK1-Cy5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 348.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK5-Cy5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6152.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

We have no information about specific commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

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