The importance of copy numbers in genetic diagnostics and research
Copy number variants play a role in many genetic disorders. The fast, accurate and affordable detection of CNVs is essential for clinical genetic testing and research.
MRC Holland develops tools for the detection of DNA copy numbers and methylation patterns associated with disease. Our MLPA® technique is the gold standard in this field, and is used around the world to study hereditary disorders and tumours.
Latest News
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Oct 02, 2025Improved – P242 Pancreatitis – Now Featuring Mutation-Specific Probes for SPINK1 and PRSS1
P242 Pancreatitis just received a major update, with the recently released D1 version featuring nine new target probes and three new mutation-specific probes, as well as three replaced target probes and eight replaced reference probes. The updated probe content facilitates enhanced detection of HP-related genetic alterations and improves assay robustness.
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Oct 02, 2025MRC Holland Visiting Scientist to Present on Newborn Screening at International Conferences
Terence Diane Fabella, a PhD candidate and MRC Holland researcher, will present her work on the development of digitalMLPA assays for newborn screening at three international conferences later this year.
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Oct 02, 2025Coming Soon - Two New digitalMLPA Assays
Exciting news about our digitalMLPA portfolio – two new digitalMLPA™ assays will be launched soon: NXtec™ D002 Hereditary Cancer Panel 2 and NXtec™ D024 KaryoProfiler!
Come and Meet Us
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Oct 14, 2025 - Boston, USA
Visit us at ASHG 2025
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Oct 20, 2025 - Amsterdam, The Netherlands
Visit us at SIOP 2025
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Nov 06, 2025 - 16:00-20:00 CET
Virtual Workshop: MLPA Raw Data Evaluation and Troubleshooting
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Nov 11, 2025 - Boston, USA
Visit us at AMP 2025
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Nov 20, 2025 - 16:00-20:00 CET
Virtual Workshop: MLPA Data Analysis and Quality Control with Coffalyser.Net