Choose your country to see the products for your location

P446 GALC

SALSA MLPA Probemix P446 GALC detects copy number variations in the GALC gene.

Specifications

Contents: 28 MLPA probes, including 19 probes for GALC (covering all exons).

Tissue: human genomic DNA.

Application: research on Krabbe disease.

For research use only (RUO). Not for use in diagnostics.

Quick links

List Prices Documentation

General information

The SALSA MLPA Probemix P446 GALC is a research use only (RUO) assay for the detection of deletions or duplications in the GALC gene, which is associated with Krabbe disease.

Krabbe disease is an autosomal recessive lysosomal disorder affecting the white matter of the central and peripheral nervous systems. Krabbe disease is caused by homozygous or compound heterozygous mutations in the GALC gene on chromosome 14q31.3. The protein encoded by this gene is galactosylceramidase, which is a lysosomal enzyme involved in the catabolism of galactosylceramide, a major lipid in myelin, kidney, and epithelial cells of the small intestine and colon.

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK1238/.

Regulatory status

SALSA MLPA Probemix P446 GALC is for research use only (RUO) in all territories.

Product documentation

Version A2

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P446-025R
SALSA MLPA Probemix P446 GALC – 25 rxn
MLPA
€ 296.00
P446-050R
SALSA MLPA Probemix P446 GALC – 50 rxn
MLPA
€ 580.00
P446-100R
SALSA MLPA Probemix P446 GALC – 100 rxn
MLPA
€ 1135.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 361.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 361.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6373.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

The commercially available positive samples below can be used with the current (A2) version of this product.

  • Coriell NA04372: Heterozygous deletion affecting the probes for GALC Exon 11-17.
  • Coriell NA04517: Homozygous deletion affecting the probes for GALC Exon 11-17.

Resources

General MLPA resources

MLPA education

This site uses cookies to help improve your online experience. Learn more
No, thank you accept

Sign in

Don't have an account? Create one

Forgot password?

Select Your Country

Choose your country to see the products for your location