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P266 CLCNKB

SALSA MLPA Probemix P266 CLCNKB detects copy number variations in the CLCNKB and CLCNKA genes.

Specifications

Contents: 29 MLPA probes, including 14 probes for CLCNKB, and 2 probes for CLCNKA.

Tissue: human genomic DNA.

Application: research on Bartter syndrome.

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

P136 Gitelman Syndrome

Contains probes for the SLC12A3 gene involved in Gitelman Syndrome.

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General information

The SALSA MLPA Probemix P266 CLCNKB is a research use only (RUO) assay for the detection of deletions or duplications in the CLCNKB and CLCNKA genes, which are associated with Bartter syndrome.

Bartter syndrome refers to a group of disorders in which salt reabsorption in the thick ascending loop of Henle is impaired by approximately 70%. The phenotype of this syndrome is characterised by short stature, hyperactive renin-angiotensin system, lack of effect of angiotensin on blood pressure, renal potassium wasting, increased renal prostaglandin production, and occasionally hypomagnesemia. At present, four types of Bartter syndrome have been identified:

  • Antenatal Bartter syndrome type 1 and 2 are caused by loss-of-function mutations in the SLC12A1 gene and KCNJ1 gene, respectively.
  • Bartter syndrome type 3 is due to mutations in the kidney chloride channel B (CLCNKB) gene.
  • Bartter syndrome type 4 (or infantile Bartter syndrome with sensorineural deafness) results from mutations of the BSND gene (type 4A) or by simultaneous mutations in both the CLCNKA and CLCNKB genes (type 4B).

Regulatory status

SALSA MLPA Probemix P266 CLCNKB is for research use only (RUO) in all territories.

Product documentation

Version B2

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P266-025R
SALSA MLPA Probemix P266 CLCNKB – 25 rxn
MLPA
€ 286.00
P266-050R
SALSA MLPA Probemix P266 CLCNKB – 50 rxn
MLPA
€ 560.00
P266-100R
SALSA MLPA Probemix P266 CLCNKB – 100 rxn
MLPA
€ 1096.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 348.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 348.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6152.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

We have no information about specific commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

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