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SALSA MLPA Probemix P181 Centromere mix 1

Centromeric testing

Region: Centromeres

General information
The SALSA MLPA Probemix P181 Centromere mix 1 is a research use only (RUO) assay for the detection of deletions or duplications in genes close to the centromeres of all chromosomes, with the exception of the Y-chromosome. In most cases, probes are included for the first well-characterised gene in the centromeric region. Possible applications of this probemix are in cancer research, as well as for characterisation of marker chromosomes and the detection of aneuploidies.

This SALSA MLPA probemix is not CE/FDA registered for use in diagnostic procedures. Purchase of this product includes a limited license for research purposes.

Probemix content
The SALSA MLPA Probemix P181-C1 Centromere mix 1 contains 46 MLPA probes with amplification products between 127 and 450 nucleotides (nt). This includes one probe for each of the chromosome arms (except the Y-chromosome). For the acrocentric chromosomes (13, 14, 15, 21 and 22), which have more than 10 Mb of repeat sequences at one end covering most or all of the p-arms, there are two probes on the q-arm, close to the centromere. The SALSA MLPA Probemix P182 Centromere mix 2 detects different sequences in the same regions. Complete probe sequences are available online (www.mrcholland.com).

This probemix contains ten quality control fragments generating amplification products between 64 and 121 nt: four DNA Quantity fragments (Q-fragments), two DNA Denaturation fragments (D-fragments), one Benchmark fragment, and one chromosome X and two chromosome Y-specific fragments. More information on how to interpret observations on these control fragments can be found in the MLPA General Protocol and online at www.mrcholland.com.

Order Items

Probemix

Item no.
Description
Technology
Price
P181-025R
SALSA MLPA Probemix P181 Centromere mix 1 – 25 rxn
€ 243.00
P181-050R
SALSA MLPA Probemix P181 Centromere mix 1 – 50 rxn
€ 486.00
P181-100R
SALSA MLPA Probemix P181 Centromere mix 1 – 100 rxn
€ 972.00

Required Reagents (Sold Separately)

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA EK1 reagent kit – 100 rxn – FAM
€ 300.00
EK1-Cy5
SALSA MLPA EK1 reagent kit – 100 rxn – Cy5
€ 300.00
EK5-FAM
SALSA MLPA EK5 reagent kit – 500 rxn – FAM
€ 1380.00
EK5-Cy5
SALSA MLPA EK5 reagent kit – 500 rxn – Cy5
€ 1380.00
EK20-FAM
SALSA MLPA EK20 reagent kit – 2000 rxn – FAM
€ 5295.00

Related Products

SALSA MLPA Probemix P036 Subtelomeres Mix 1

Contains one probe for each of the 41 subtelomeric regions and 5 probes near the centromeric regions of the five acrocentric chromosomes.

SALSA MLPA Probemix P070 Subtelomeres Mix 2B

Contains one probe for each of the 41 subtelomeric regions and 5 probes near the centromeric regions of the five acrocentric chromosomes.

SALSA MLPA Probemix P095 Aneuploidy

Contains probes for chromosomes 13, 18, 21, X and Y.

SALSA MLPA Probemix P182 Centromere mix 2

Contains probes that detect the same regions but different sequences compared to the probes of P181 Centromere mix 1.

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