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There is a wealth of literature describing MLPA as the gold standard for germline detection of intragenic copy number alterations in tumour suppressor genes BRCA1, BRCA2, and RAD51C.
Did you know that promoter methylation of these genes also contributes to the progression of hereditary breast and ovarian cancer? This is why we have designed the new methylation-specific SALSA MLPA Probemix ME053 BRCA1-BRCA2-RAD51C for determination of methylation status of BRCA1, BRCA2 and RAD51C promoter regions in DNA from germline or somatic origin.
If you are interested in hearing more about BRCA1, BRCA2, and RAD51C copy number and methylation detection, you can visit the poster of our colleague Gemma Montalban during BRCA 2023.
This product is for Research Use Only (RUO). Not for use in diagnostic procedures.