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SALSA MLPA Probemix P462 Follicular Lymphoma

Follicular lymphoma

Region: Various

General information: The SALSA MLPA Probemix P462 Follicular Lymphoma is a research use only (RUO) assay for the detection of deletions or duplications in several genes and chromosomal regions involved in follicular lymphoma development.

Follicular lymphoma (FL) represents about 20% of all lymphomas worldwide, making it the second most common subtype of lymphomas. Approximately 85% of FL carry the translocation t(14;18)(q32;q21), which results in the constitutive overexpression of the anti-apoptotic protein BCL2 and allows B-cells to escape the normal anti-apoptotic program. However, BCL2 overexpression alone is not sufficient for lymphomagenesis, as additional genetic defects appear to be important, such as loss of 1p (TNFRSF14), 6q (EPHA7, PRDM1, TNFAIP3), 9p (CDKN2A/2B), 10q (PTEN, FAS), 15q (B2M) and 17p (TP53) and gain of 1q, 2p (REL, BCL11A), 3q (BCL6), 7q (EZH2), 8q (MYC), 12q, 18q (MALT1, BCL2) and Xp11 (BCOR, KDM6A).

Probemix content: The SALSA MLPA Probemix P462-B1 Follicular Lymphoma contains 62 MLPA probes with amplification products between 121 and 504 nt. This includes 49 probes for the genes and chromosomal regions mentioned above. In addition, 13 reference probes are included which target relatively quiet regions in terms of copy number changes in follicular lymphoma. However, it should be noticed that lymphoma karyotypes can harbour multiple numerical and structural aberrations, which can complicate interpretation of these reference probes. Complete probe sequences and the identity of the genes detected by the reference probes is available in Table 2 and online (www.mlpa.com).

This Probemix contains nine quality control fragments generating amplification products between 64 and 105 nucleotides (nt): four DNA Quantity fragments (Q-fragments), two DNA Denaturation fragments (D-fragments), one Benchmark fragment, and one chromosome X and one chromosome Y-specific fragment. More information on how to interpret observations on these control fragments can be found in the MLPA General Protocol and online at www.mlpa.com.

Order Items

Probemix

Item no.
Description
Technology
Price
P462-025R
SALSA MLPA Probemix P462 Follicular Lymphoma – 25 rxn
€ 243.00
P462-050R
SALSA MLPA Probemix P462 Follicular Lymphoma – 50 rxn
€ 486.00
P462-100R
SALSA MLPA Probemix P462 Follicular Lymphoma – 100 rxn
€ 972.00

Required Reagents (Sold Separately)

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA EK1 reagent kit – 100 rxn – FAM
€ 300.00
EK1-Cy5
SALSA MLPA EK1 reagent kit – 100 rxn – Cy5
€ 300.00
EK5-FAM
SALSA MLPA EK5 reagent kit – 500 rxn – FAM
€ 1380.00
EK5-Cy5
SALSA MLPA EK5 reagent kit – 500 rxn – Cy5
€ 1380.00
EK20-FAM
SALSA MLPA EK20 reagent kit – 2000 rxn – FAM
€ 5295.00

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Improvements

Seven target probes replaced, nine reference probes replaced and one reference probe added. Two targ