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20 years of SALSA MLPA: past, present & future

May 20, 2022

June 2022 marks the 20th anniversary of the publication of Jan Schouten’s hallmark paper: Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification in Nucleic Acids Research. This is a milestone for all of us, since this publication was the start of MRC Holland as we know it today.


Initially founded in 1985 in Amsterdam, the Netherlands, MRC Holland was primarily focused on the production of restriction enzymes and molecular weight markers. This focus subsequently shifted towards the development of new techniques for DNA analysis such as MLPA, which would ultimately become the gold standard for copy number determination.


With more than 100 employees from 33 nations, the company has grown significantly over the last 2 decades – and so did our product portfolio! More than 400 genetic assays have been developed in the past 20 years. In the past 5 years, two additional techniques have been added to our repertoire: Melt Assay and digitalMLPA. Currently, MRC Holland offers more than 350 products for copy number detection.


The company’s mission in the future will be to continue providing high-quality products at a fair price. We will continue our mission to provide reliable and affordable assays to labs around the world. Our aim will be to keep improving our existing assays and develop new ones with the needs of our customers in mind.

To us, it is a sign of confidence that we are able to celebrate the 20th anniversary of such a milestone – therefore we thank you, our customers, for your continued trust in us and our products!

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